Abstract. Control trials show that fluoxetine is effective in Eating Disorders, particularly in bulimia nervosa. Despite the relative paucity of evidence other selective serotonine reuptake inhibitors (SSRIs) than fluoxetine are commonly used to treat bulimia nervosa in clinical practice. Sertraline is one of the SSRIs being used in Eating Disorders with binging and purging behaviors. Available evidence show promising data about the effect of sertraline on eating disorder’s psychopathology, but there seem to be contrasting data about sertraline’s effect on body weight. We report seven cases of women with Bulimia Nervosa who reduced eating disorder core behaviors and maintained or lost weight in response to sertraline.